We stand at the frontiers of chemistry and biology, developing small molecules as chemical tools to understand and modulate complex biological systems. We utilize synthetic chemistry, biochemistry, and state-of-the art mass spectrometry to elucidate the structure, dynamics, and reactivity of poorly characterized, previously "undruggable" members of the proteome with pathological implications (e.g. cancer, diabetes, infectious diseases).
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Latest Lab News

Congrats Daniel (and all authors) on publishing this impressive article in Nature Communications!
May 30, 2025
Check out this interesting article where a high throughput screening approach using covalent electrophiles is executed to identify inhibitors of Staphylococcus aureus serine hydrolases FphB, FphE and FphH now online in Nature Communications!

Congratulations Dr. Qiu!
April 16, 2025
Exciting news as Nan completes her PhD Thesis Dissertation titled "Decoding Chemical Reactivities of the Native Proteome: Strategies to Target the Undruggable". We are immensely happy for you!

Congrats Daniel (and all authors) on publishing this impressive article in Nature Communications!
April 15, 2025
Check out this interesting article which utilizes in-vivo stable N-hydroxysuccinimide (NHS)-ester-based amine crosslinking of fluorescent dyes to uniformly label live mammalian cell surface proteins now online in Nature Communications!
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Lab Culture
We strive to make our lab a family by cultivating a fun yet hardworking lab environment. We regularly partake in lab events, such lab dinners and team-building activities.