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We stand at the frontiers of chemistry and biology, developing small molecules as chemical tools to understand and modulate complex biological systems. We utilize synthetic chemistry, biochemistry, and state-of-the art mass spectrometry to elucidate the structure, dynamics, and reactivity of poorly characterized, previously "undruggable" members of the proteome with pathological implications (e.g. cancer, diabetes, infectious diseases). 

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Latest Lab News 
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Congrats Daniel (and all authors) on publishing this impressive article in Nature Communications!

May 30, 2025

 

Check out this interesting article where a high throughput screening approach using covalent electrophiles is executed to identify inhibitors of Staphylococcus aureus serine hydrolases FphB, FphE and FphH now online in Nature Communications!

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Congratulations Dr. Qiu!

April 16, 2025

 

Exciting news as Nan completes her PhD Thesis Dissertation titled "Decoding Chemical Reactivities of the Native Proteome: Strategies to Target the Undruggable". We are immensely happy for you!

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Congrats Daniel (and all authors) on publishing this impressive article in Nature Communications!

April 15, 2025

 

Check out this interesting article which utilizes in-vivo stable N-hydroxysuccinimide (NHS)-ester-based amine crosslinking of fluorescent dyes to uniformly label live mammalian cell surface proteins now online in Nature Communications!

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Lab Culture

We strive to make our lab a family by cultivating a fun yet hardworking lab environment. We regularly partake in lab events, such lab dinners and team-building activities.

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