Publications
85
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera
Yuquan Tong, Peiyuan Zhang, Xueyi Yang, Xiaohui Liu, Jie Zhang, Magda Grudniewska, Ikrak Jung, Daniel Abegg, Jun Liu, Jessica Childs-Disney, Quentin Gibaut, Hafeez Haniff, Alexander Adibekian, Maral Mouradian, Matthew Disney
Proc. Natl. Acad. Sci. 2024, doi.org/10.1073/pnas.2306682120
84
Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide
Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, Groll M, Adibekian A, Renata H, Trauner D.
Angew. Chem. Int. Ed. Engl. 2023, doi:10.1002/anie.202314791
83
Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity
Blessy M. Suresh, Yuquan Tong, Daniel Abegg, Alexander Adibekian, Jessica L. Childs-Disney, and Matthew D. Disney*
82
Programming Inactive RNA-binding Small Molecules into Bioactive Degraders
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius*, Herbert Waldmann*, and Matthew D. Disney*
81
Chaperone-directed Ribosome Repair After Oxidative Damage
Yoon-Mo Yang, Youngeun Jung, Daniel Abegg, Alexander Adibekian, Kate S. Carroll, and Katrin Karbstein*
80
Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows
Franco F. Faucher, Daniel Abegg, Phillip Ipock, Alexander Adibekian, Scott Lovell, and Matthew Bogyo*
79
Serine Hydrolase Activity-Based Probes for use in Chemical Proteomics
Brittney Racioppo, Nan Qiu, and Alexander Adibekian*
Isr. J. Chem. 2023 e202300016
78
Comprehensive Structure–Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations
Alexander Amatuni, Anton Shuster, Daniel Abegg, Alexander Adibekian*, and Hans Renata*
ACS Cent. Sci. 2023, 9, 239-251
77
Sesquiterpenoid Analogs
Mingji Dai, Dexter Cameron Davis, Alexander Adibekian, Dominic Gregor Hoch, and Zhong-Yin Zhang
76
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC)
Samantha M. Meyer, Toru Tanaka, Patrick R. A. Zanon, Jared T. Baisden, Daniel Abegg, Xueyi Yang, Yoshihiro Akahori, Zainab Alshakarchi, Michael D. Cameron, Alexander Adibekian, and Matthew D. Disney*
J. Am. Chem. Soc. 2022, 144, 21096-21102
75
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA
Yuquan Tong, Quentin M R Gibaut, Warren Rouse, Jessica L Childs-Disney, Blessy M Suresh, Daniel Abegg, Shruti Choudhary, Yoshihiro Akahori, Alexander Adibekian, Walter N Moss, Matthew D Disney*
J. Am. Chem. Soc. 2022, 144, 11620-11625
74
Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis Through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk
Flavien Berthou, Cyril Sobolewski, Daniel Abegg, Margot Fournier, Christine Maeder, Dobrochna Dolicka, Marta Correia de Sousa, Alexander Adibekian, and Michelangelo Foti*
Int. J. Mol. Sci. 2022, 23, 3959
73
The Pseudo-Natural Product Rhonin Targets RHOGDI
Mohammad Akbarzadeh, Jana Flegel, Sumersing Patil, Erchang Shang, Rishikesh Narayan, Marcel Buchholzer, Neda S. Kazemein Jasemi, Michael Grigalunas, Adrian Krzyzanowski, Daniel Abegg, Anton Shuster, Marco Potowski, Hacer Karatas, George Karageorgis, Niloufar Mosaddeghzadeh, Mia-Lisa Zischinsky, Christian Merten, Christopher Golz, Lucas Brieger, Carsten Strohmann, Andrey P. Antonchick, Petra Janning, Alexander Adibekian, Roger S. Goody, Mohammad Reza Ahmadian, Slava Ziegler, and Herbert Waldmann*
Angew. Chem. Int. Ed. 2022, e202115193
72
DNA-encoded Library Versus RNA-Encoded Library Selection Enables Design of an Oncogenic Noncoding RNA Inhibitor
Raphael I. Benhamou, Blessy M. Suresh, Yuquan Tong, Wesley G. Cochrane, Valerie Cavett, Simon Vezina-Dawod, Daniel Abegg, Jessica L. Childs-Disney, Alexander Adibekian, Brian M. Paegel*, and Matthew D. Disney*
Proc. Natl. Acad. Sci. 2022, 119(6), e2114971119
71
Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA
Fei Ye, Hafeez S. Haniff, Blessy M. Suresh, Dong Yang, Peiyuan Zhang, Gogce Crynen, Christiana N. Teijaro, Wei Yan, Daniel Abegg, Alexander Adibekian, Ben Shen*, and Matthew D. Disney*
ACS Chem. Biol. 2022, 17, 474-482
70
Artemisinin Inhibits NRas Palmitoylation by Targeting the Protein Acyltransferase ZDHHC6
Nan Qiu, Daniel Abegg, Mara Guidi, Kerry Gilmore, Peter H. Seeberger, and Alexander Adibekian*
Cell Chem. Biol. 2022, 29, 539-537
69
Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway
Daniel Abegg, Martin Tomanik, Nan Qiu, Dany Pechalrieu, Anton Shuster, Bruno Commare, Antonio Togni, Seth B. Herzon, and Alexander Adibekian*
J. Am. Chem. Soc. 2021, 143, 20332-20342
68
Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein
Anton Shuster, Dany Pechalrieu, Cody B. Jackson, Daniel Abegg, Hyeryun Choe, and Alexander Adibekian*
ACS Chem. Biol. 2021, 16, 2845-2851
67
Dichloro Butendiamides as Irreversible Site-Selective Protein Conjugation Reagent
Victor Laserna, Daniel Abegg, Cláudia Afonso, Esther Martin, Alexander Adibekian, Peter Ravn, Francisco Corzana, and Gonçalo J. L. Bernardes*
Angew. Chem. Int. Ed. 2021, 60, 23750-23755
66
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
Peiyuan Zhang, Xiaohui Liu, Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I. Benhamou, Jared Baisden, Gogce Crynen, Samantha M. Meyer, Michael D. Cameron, Arnab K. Chatterjee, Alexander Adibekian, Jessica L. Childs-Disney, and Matthew D. Disney*
J. Am. Chem. Soc. 2021, 143, 13044-13055
65
Total Synthesis and Target Identification of the Curcusone Diterpenes
Chengsen Cui,# Brendan G. Dwyer,# Chang Liu, Daniel Abegg, Zhong-Jian Cai, Dominic G. Hoch, Xianglin Yin, Nan Qiu, Jie-Qing Liu, Alexander Adibekian*, and Mingji Dai*
J. Am. Chem. Soc. 2021, 143, 4379-4386
64
A Structure-Specific Small Molecule Inhibits a miRNA-200 Family Member Precursor and Reverses a Type 2 Diabetes Phenotype
Hafeez S. Haniff, Xiaohui Liu, Yuquan Tong, Samantha M. Meyer, Laurent Knerr, Malin Lemurell, Daniel Abegg, Haruo Aikawa, Alexander Adibekian, and Matthew D. Disney*
Cell Chem. Biol. 2020, 27, 1371-1382
63
Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development
Monika Gjorgjieva, Cyril Sobolewski, Anne-Sophie Ay, Daniel Abegg, Marta Correia de Sousa, Dorothea Portius, Flavien Berthou, Margot Fournier, Christine Maeder, Pia Rantakari, Fu-Ping Zhang, Matti Poutanen, Didier Picard, Xavier Montet, Serge Nef , Alexander Adibekian, and Michelangelo Foti*
J. Pers. Med. 2020, 10, 170
62
Chemoproteomics‐Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism
Brendan Dwyer, Chao Wang, Daniel Abegg, Brittney Racioppo, Nan Qiu, Zhensheng Zhao, Dany Pechalrieu, Anton Shuster, Dominic Hoch, and Alexander Adibekian*
Angew. Chem. Int. Ed. 2021, 60, 3071-3079
61
Design of a Small Molecule That Stimulates Vascular Endothelial Growth Factor A Enabled by Screening RNA Fold–Small Molecule interactions
Hafeez S. Haniff, Laurent Knerr, Xiaohui Liu, Gogce Crynen, Jonas Boström, Daniel Abegg, Alexander Adibekian, Elizabeth Lekah, Kye Won Wang, Michael D. Cameron, Ilyas Yildirim, Malin Lemurell, and Matthew D. Disney*
Nature Chemistry 2020, 12, 952-961
60
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
Paige Dickson, Daniel Abegg, Ekaterina Vinogradova, Junichiro Takaya, Hongchan An, Scott Simanski, Benjamin F. Cravatt, Alexander Adibekian, and Thomas Kodadek*
Cell Chem. Biol. 2020, 27, 1371-1382
59
Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I
Alexander Amatuni, Anton Shuster, Alexander Adibekian,* and Hans Renata*
Cell Chem. Biol. 2020, 27, 1318-1326
58
Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex
Dominic G. Hoch, Daniel Abegg, J. Thomas Hannich, Dany Pechalrieu, Anton Shuster, Brendan Dwyer, Chao Wang, Xiaojin Zhang, Qidong You, Howard Riezman, and Alexander Adibekian*
Cell Chem. Biol. 2020, 27, 586-597
57
Ethynylation of Cysteines from Peptides to Proteins in Living Cells
Romain Tessier, Raj Kumar Nandi, Brendan G. Dwyer, Daniel Abegg, Charlotte Sornay, Javier Ceballos, Stephane Erb, Sarah Cianferani, Alain Wagner, Guilhem Chaubet*, Alexander Adibekian*, and Jerome Waser*
Angew. Chem. Int. Ed. 2020, 59, 10961-10970
56
Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands
Xiaohui Liu, Hafeez S. Haniff, Jessica L. Childs-Disney, Anton Shuster, Haruo Aikawa, Alexander Adibekian, and Matthew D. Disney*
J. Am. Chem. Soc. 2020, 142, 6970-6982
55
Small-Molecule Targeted Recruitment of a Nuclease to Cleave an Oncogenic RNA in a Mouse Model of Metastatic Cancer
Matthew G. Costales, Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi, Yoshio Nakai, Tanya Khan, Kye Won Wang, Ilyas Yildirim, Alexander Adibekian, Eric T. Wang, and Matthew D. Disney*
Proc. Natl. Acad. Sci. 2020, 117, 2406-2411
54
S100A11/ANXA2 Belongs to a Tumour Suppressor/Oncogene Network Deregulated Early with Steatosis and Involved in Inflammation and Hepatocellular Carcinoma Development
Cyril Sobolewski, Daniel Abegg, Flavien Berthou, Dobrochna Dolicka, Nicolas Calo, Christine Sempoux, Margot Fournier, Christine Maeder, Anne-Sophie Ay, Pierre-Alain Clavien, Bostjan Humar, Jean-François Dufour, Alexander Adibekian, and Michelangelo Foti*
Gut 2020, 69, 1841-1854
53
Translation of the Intrinsically Disordered Protein α-Synuclein is Inhibited by a Small Molecule Targeting its Structured mRNA
Peiyuan Zhang, Hye-Jin Park, Jie Zhang, Eunsung Junn, Ryan J. Andrews, Sai Pradeep Velagapudi, Daniel Abegg, Kamalakannan Vishnu, Matthew G. Costales, Jessica L. Childs-Disney, Alexander Adibekian, Walter N. Moss, M. Maral Mouradian, and Matthew D. Disney*
Proc. Natl. Acad. Sci. 2020, 117, 1457-1467
52
1-Deoxydihydroceramide Causes Anoxic Death by Impairing Chaperonin-Mediated Protein Folding
J. Thomas Hannich, A. Galih Haribowo, Sébastien Gentina, Melanie Paillard, Ludovic Gomez, Bruno Pillot, Hélène Thibault, Daniel Abegg, Nicolas Guex, Andreas Zumbuehl, Alexander Adibekian, Michel Ovize, Jean-Claude Martinou, and Howard Riezman*
Nat. Metab. 2019, 1, 996-1008
51
Discovery and Evaluation of Novel Activity-Based Probes for Serine Hydrolases
Chao Wang, Daniel Abegg, Brendan G. Dwyer,* and Alexander Adibekian*
ChemBioChem 2019, 20, 2212-2216
50
A Designed Precision Small Molecule Inhibiting a Noncoding RNA Sensitizes HER2 Negative Cancer to Herceptin
Matthew G. Costales, Dominic G. Hoch, Daniel Abegg, Jessica L. Childs-Disney, Sai Pradeep Velagapudi, Alexander Adibekian, and Matthew D. Disney*
J. Am. Chem. Soc. 2019, 141, 2960-2974
49
Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids
Dexter C. Davis, Dominic G. Hoch, Li Wu, Daniel Abegg, Brandon S. Martin, Zhong-Yin Zhang,* Alexander Adibekian,* and Mingji Dai*
J. Am. Chem. Soc. 2018, 140, 17465-17473
48
Cysteine-Reactive Probes and their use in Chemical Proteomics
Dominic G. Hoch, Daniel Abegg, and Alexander Adibekian*
Chem. Commun. 2018, 54, 4501-4512
47
The SAGA Complex, Together with Transcription Factors and the Endocytic Protein Rvs167p, Coordinate the Reprofiling of Gene Expression in Response to Changes in Sterol Composition in Saccharomyces Cerevisiae
Gisèle Dewhurst-Maridor, Daniel Abegg, Fabrice P.A. David, Jacques Rougemont, Cameron C. Scott, Alexander Adibekian, and Howard Riezman*
Mol. Biol. Cell 2017, 28, 2637-2649
46
Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at Highest Tension
Lili Zong, Eline Bartolami, Daniel Abegg, Alexander Adibekian, Naomi Sakai, and Stefan Matile*
ACS Cent. Sci. 2017, 3, 449-453
45
Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor
Daniel Abegg, Giulio Gasparini, Dominic G. Hoch, Anton Shuster, Eline Bartolami, Stefan Matile*, and Alexander Adibekian*
J. Am. Chem. Soc. 2017, 139, 231-238
44
Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery
Dominic G. Hoch, Daniel Abegg, Chao Wang, Anton Shuster, Alexander Adibekian*
Chimia 2016, 70, 764-767
43
Divergent Synthesis and Identification of the Cellular Targets of Deoxyelephantopins
Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian,* Nicolas Winssinger*
Nat. Commun. 2016, 7, 12470
42
Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology
Alexander Adibekian*, Pierre Stallforth*
ACS Chem. Biol. 2016, 11, 816–820
41
Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA-Repair Protein MGMT
Chao Wang, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian*
Angew. Chem. Int. Ed. 2016, 55, 2911-2915
40
Proteome-Wide Profiling of Targets of Cysteine-reactive Small Molecules by using Ethynyl Benziodoxolone Reagents
Daniel Abegg, Reto Frei, Luca Cerato, Durga Prasad Hari, Chao Wang, Jerome Waser, Alexander Adibekian*
Angew. Chem. Int. Ed. 2015, 54, 10852-10857
39
Conference Report on the 50th EUCHEM Conference on Stereochemistry (Bürgenstock Conference)
Alexander Adibekian*, Thomas Magauer*
Chimia 2015, 69, 485-487
38
Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
Jean-Pierre Daguer, Claudio Zambaldo, Daniel Abegg, Sofia Barluenga, Cynthia Tallant, Susanne Müller, Alexander Adibekian, Nicolas Winssinger*
Angew. Chem. Int. Ed. 2015, 54, 6057-6061
37
Mechanistic Effects of Protein Palmitoylation and the Cellular Consequences Thereof
Sanja Blaskovic, Alexander Adibekian, Mathieu Blanc, Gisou van der Goot*
Chem. Phys. Lipids 2014, 180, 44-52
36
Characterisation of a Serine Hydrolase Targeted by Acyl Protein Thioesterase Inhibitors in Toxoplasma gondii
Louise Kemp, Marion Rusch, Alexander Adibekian, Hayley E. Bullen, Arnault Graindorge, Céline Freymond, Matthias Rottmann, Catherine Braun-Breton, Stefan Baumeister, Arthur T. Porfetye, Ingrid R. Vetter, Christian Hedberg, Dominique Soldati-Favre*
J. Biol. Chem. 2013, 288, 27002-27018
Independent Career
Previous Research
35
Omega-3 Fatty Acid Epoxides are Autocrine Mediators that Control the Magnitude of IgE-Mediated Mast Cell Activation
Yuta Shimanaka, Nozomu Kono, Yoshitaka Taketomi, Makoto Arita, Yoshimichi Okayama, Yuki Tanaka, Yasumasa Nishito, Tatsuki Mochizuki, Hiroyuki Kusuhara, Alexander Adibekian, Benjamin F Cravatt, Makoto Murakami*, and Hiroyuki Arai*
Nat. Med. 2017, 23, 1287-1297
34
A Semisynthetic Carbohydrate-Lipid Vaccine that Protects Against S. pneumoniae in Mice
Cavallari M, Stallforth P, Kalinichenko A, Rathwell DC, Gronewold TM, Adibekian A, Mori L, Landmann R, Seeberger PH, De Libero G*
Nat. Chem. Biol. 2014, 10, 950-956
33
Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA1)
Alexander Adibekian, Brent R Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A Bachovchin, Anna E Speers, Steven J Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F Cravatt, Peter Hodder, Hugh Rosen
Probe Reports from the NIH Molecular Libraries Program, 2013
32
Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)
Alexander Adibekian, Brent R Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A Bachovchin, Anna E Speers, Steven J Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F Cravatt, Peter Hodder, Hugh Rosen
Probe Reports from the NIH Molecular Libraries Program, 2013
31
Diced Electrophoresis Gel Assay for Screening Enzymes with Specified Activities
Toru Komatsu, Kenjiro Hanaoka, Alexander Adibekian, Takuya Terai, Tasuku Ueno, Mitsuyasu Kawaguchi, Benjamin F. Cravatt, Tetsuo Nagano*
J. Am. Chem. Soc. 2013, 135, 6002-6005
30
De Novo Chemoenzymatic Synthesis of Sialic Acid
Pierre Stallforth, Stefan Matthies, Alexander Adibekian, Dennis G. Gillingham, Donald Hilvert, Peter H. Seeberger*
Chem. Commun. 2012, 48, 11987-11989
29
DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses
Ku-Lung Hsu, Katsunori Tsuboi, Alexander Adibekian, Holly Pugh, Kim Masuda, Benjamin F. Cravatt*
Nat. Chem. Biol. 2012, 8, 999-1007
28
New Substituted Triazole Compounds are Serine Hydrolase Enzyme Inhibitors, Useful for Treating e.g. Obesity, Metabolic Disorders, Vomiting or Nausea, Neuropathy, Amyotrophic Lateral Sclerosis, Epilepsy and Sleep Disorders
Benjamin F. Cravatt, Alexander Adibekian, Katsunori Tsuboi, Ku-Lung Hsu
U.S. Patent No. WO2012138877-A1 (2012)
27
Confirming Target Engagement of Reversible Inhibitors in vivo by Kinetically Tuned Activity-based Probes
Alexander Adibekian, Brent R. Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A. Bachovchin, Anna E. Speers, Steven J. Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Peter S. Hodder, Hugh Rosen, Benjamin F. Cravatt*
J. Am. Chem. Soc. 2012, 134, 10345-10348
26
Optimization and Characterization of a Triazole Urea Inhibitor for Platelet-Activating Factor Acetylhydrolase Type 2 (PAFAH2)
Alexander Adibekian, Ku-Lung Hsu, Anna E Speers, Elizabeth S Monillas, Steven J Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Brian J Bahnson, Benjamin F Cravatt, Peter Hodder, Hugh Rosen
Probe Reports from the NIH Molecular Libraries Program, 2011
25
Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211
Alexander Adibekian, Ku-Lung Hsu, Anna E Speers, Steven J Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F Cravatt, Peter Hodder, Hugh Rosen
Probe Reports from the NIH Molecular Libraries Program, 2011
24
Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)
Alexander Adibekian, Brent Martin, Anna E Speers, Steven J Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F Cravatt, Peter Hodder, Hugh Rosen
Probe Reports from the NIH Molecular Libraries Program, 2011
23
Global Profiling of Dynamic Protein Palmitoylation
Brent R. Martin, Chu Wang, Alexander Adibekian, Sarah E. Tully, Benjamin F. Cravatt*
Nat. Methods 2011, 9, 84-89
22
A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile is Antigenic and Immunogenic
Matthias Oberli, Marie-Lyn Hecht, Pascal Bindschädler, Thomas Adam, Alexander Adibekian, Peter H. Seeberger*
Chem. Biol. 2011, 18, 580-588
21
Comparative Bioinformatics Analysis of the Mammalian and Bacterial Glycomes
Alexander Adibekian, Pierre Stallforth, Marie-Lyn Hecht, Daniel B. Werz, Pascal Gagneux, Peter H. Seeberger*
Chem. Sci. 2011, 2, 337-344
20
Click-Chemistry Generated Triazole Ureas as Ultrapotent, in vivo-Active Serine Hydrolase Inhibitors
Alexander Adibekian, Brent R. Martin, Chu Wang, Ku-Lung Hsu, Daniel A. Bachovchin, Sherry Niessen, Heather Hoover, Benjamin F. Cravatt*
Nat. Chem. Biol. 2011, 7, 469-478
19
Supefamily-wide Portrait of Serine Hydrolase Inhibition Achieved by Library-versus-Library Screening
Daniel A. Bachovchin, Tianyang Ji, Weiwei Li, Gabriel M. Simon, Jacqueline L. Blankman, Alexander Adibekian, Heather Hoover, Sherry Niessen, Benjamin F. Cravatt*
Proc. Natl. Acad. Sci. 2010, 107, 20941-20946
18
Molecular Analysis of Carbohydrate-Antibody Interactions: Case Study Using a Bacillus anthracis Tetrasaccharide
Matthias Oberli, Marco Tamborrini, Yu-Hsuan Tsai, Daniel B. Werz, Tim Horlacher, Alexander Adibekian, Dominik Gauss, Heiko M. Möller, Gerd Pluschke, Peter H. Seeberger*
J. Am. Chem. Soc. 2010, 132, 10239-10241
17
Towards the Synthesis of a Yersinia Pestis Cell Wall Polysaccharide: Enantioselective Synthesis of L-glycero-D-manno-heptose Building Blocks
Takafumi Ohara, Alexander Adibekian, Davide Esposito, Pierre Stallforth, Peter H. Seeberger*
Chem. Commun. 2010, 46, 4106-4108
16
Facile Synthesis of Size Dependent Ru(II)- Carbohydrate Dendrimers via Click Chemistry
Kikkeri Raghavendra, Xinyu Liu, Alexander Adibekian, Yu-Hsuan Tsai, Peter H. Seeberger*
Chem. Commun. 2010, 46, 2197-2199
15
De Novo Synthesis of Differentially Protected L Iduronic Acid Glycosylating Agents
Pascal Bindschädler, Alexander Adibekian, Dan Grünstein, Peter H. Seeberger*
Carbohydr. Res. 2010, 345, 948-955
14
Chemoenzymatic Synthesis of Differentially Protected 3-Deoxysugars
Dennis G. Gillingham, Pierre Stallforth, Alexander Adibekian, Peter H. Seeberger, Donald Hilvert*
Nat. Chem. 2010, 2, 102-105
13
Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases
Jonathan Z. Long, Xin Jin, Alexander Adibekian, Weiwei Li, Benjamin F. Cravatt*
J. Med. Chem. 2010, 53, 1830-1842
12
In Vitro Imaging and In Vivo Liver Targeting with Carbohydrate Capped Quantum Dots
Kikkeri Raghavendra, Bernd Lepenies, Alexander Adibekian, Paola Laurino, Peter H. Seeberger*
J. Am. Chem. Soc. 2009, 131, 2110-2112
11
Recent Advances in Carbohydrate-based Vaccines
Marie-Lyn Hecht, Pierre Stallforth, Daniel V. Silva, Alexander Adibekian, Peter H. Seeberger*
Curr. Opin. Chem. Biol. 2009, 13, 354-359
10
Carbohydrates: A Frontier in Medicinal Chemistry
Pierre Stallforth, Bernd Lepenies, Alexander Adibekian, Peter H. Seeberger*
J. Med. Chem. 2009, 52, 5561-5577
9
Stereocontrolled Synthesis of Fully Functionalized D-Glucosamine Monosaccharides via a Domino Nitro-Michael/Henry Reaction
Alexander Adibekian, Mattie S. M. Timmer, Pierre Stallforth, Jimmy van Rijn, Daniel B. Werz, Peter H. Seeberger*
Chem. Commun. 2008, 3549-3551
8
De Novo Synthesis of a D-Galacturonic Acid Thioglycoside as Key to the Total Synthesis of a Glycosphingolipid from Sphingomonas yanoikuyae
Pierre Stallforth, Alexander Adibekian, Peter H. Seeberger*
Org. Lett. 2008, 10, 1573-1576
7
Exploring the Structural Diversity of Mammalian Carbohydrates (“Glycospace”) by Statistical Databank Analysis
Daniel B. Werz, Rene Ranzinger, Stephan Herget, Alexander Adibekian, Claus Wilhelm von der Lieth, Peter H. Seeberger*
ACS Chem. Biol. 2007, 2, 685-691
6
Convergent Synthesis of Carbohydrate Building Blocks
Peter H. Seeberger, Alexander Adibekian, Mattie S.M. Timmer
International Patent No. WO/2007/099392 (2007)
5
De Novo Synthesis of Uronic Acid Building Blocks for Assembly of Heparin Oligosaccharides
Alexander Adibekian, Pascal Bindschädler, Mattie S. M. Timmer, Christian Noti, Nina Schützenmeister, Peter H. Seeberger*
Chem. Eur. J. 2007, 13, 4510-4522
4
Synthesis of a Spore Surface Pentasaccharide of Bacillus anthracis
Daniel B. Werz, Alexander Adibekian, Peter H. Seeberger*
Eur. J. Org. Chem. 2007, 12, 1976-1982
3
Total Synthesis of Cyclic Diterpene Tonantzitlolone Based on a Highly Stereoselective Substrate-Controlled Aldol Reaction and Ring-Closing Metathesis
Christian Jasper, Alexander Adibekian, Torsten Busch, Monika Quitschalle, Rüdiger Wittenberg, Andreas Kirschning*
Chem. Eur. J. 2006, 12, 8719-8734
2
Short De Novo Synthesis of Fully Functionalized Uronic Acid Monosaccharides
Mattie S.M. Timmer, Alexander Adibekian, Peter H. Seeberger*
Angew. Chem. Int. Ed. 2005, 44, 7605-7607
1
Practical TEMPO-mediated Oxidations of Alcohols using Different Polymer-Bound Co-Oxidants
Katrin Kloth, Marco Brünjes, Eike Kunst, Thomas Jöge, Florian Gallier, Alexander Adibekian, Andreas Kirschning*
Adv. Synth. Catal. 2005, 347, 1423-1434
